People Dr Dawn O'Reilly
James Martin Fellow, Oxford Stem Cell Institute
James Martin Research Fellow
I have recently discovered a small subset of non-coding (nc)RNAs, which are expressed in human stem cells and subjected to negative regulation during differentiation. These ncRNAs play important roles in regulating the final RNA output from our protein coding genes by forming intimate interactions with the newly made RNA and two protein complexes, the Spliceosome and Polyadenylation complexes. Using the latest molecular biology and deep sequencing techniques, my work focuses on determining the specific role of these ncRNAs in stem cell biology.