In their early years, e-Science and cyberinfrastructure were dominated by heroic science using heroic infrastructures. But now we are seeing researchers across all disciplines taking advantage of new technologies to do new research. Much of this user-centred activity is drawing on the Web as a distributed application platform, with mash-ups for integration, easy access to resources "in the cloud", and social networking to share the pieces and practice of digital science. As in other walks of life, the new technologies are empowering the individual, a trend set to continue with the increasing power of the multicore desktop. This evolution throws some of our existing approaches, epitomised by the Grid, into question. Adopting a user and application perspective, this talk will present a definition of the New e-Science. It will also discuss how we might create a flourishing ecosystem of scientists, software developers and service providers rather than just a pipeline of infrastructure provision.