Blood Pressure Lowering in Type 2 Diabetes A Systematic Review and Meta-analysis

10 February 2015

JAMA. 2015;313(6):603-615. doi:10.1001/jama.2014.18574. Connor A. Emdin, HBSc; Kazem Rahimi, DM, MSc; Bruce Neal, PhD; Thomas Callender, MBChB; Vlado Perkovic, PhD; Anushka Patel, PhD

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Importance Lowering blood pressure (BP) is widely used to reduce vascular risk in individuals with diabetes.

Objective To determine the associations between BP–lowering treatment and vascular disease in type 2 diabetes.

Main outcomes and measures All-cause mortality, cardiovascular events, coronary heart disease events, stroke, heart failure, retinopathy, new or worsening albuminuria, and renal failure.

Conclusion and relevance Among patients with type 2 diabetes, BP lowering was associated with improved mortality and other clinical outcomes with lower RRs observed among those with baseline BP of 140 mm Hg and greater. These findings support the use of medications for BP lowering in these patients.