European Heart Journal

Shishir Rao, Milad Nazarzadeh, Dexter Canoy, Yikuan Li, Jing Huang, Mohammad Mamouei, Gholamreza Salimi-Khorshidi, Aletta E Schutte, Bruce Neal, George Davey Smith, Kazem Rahimi, Sodium-based paracetamol: impact on blood pressure, cardiovascular events, and all-cause mortality, European Heart Journal, 2023;, ehad535, https://doi.org/10.1093/eurheartj/ehad535

Effervescent formulations of paracetamol containing sodium bicarbonate have been reported to associate with increased blood pressure and a higher risk of cardiovascular diseases and all-cause mortality. Given the major implications of these findings, the reported associations were re-examined.